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About PierianDx

Next Generation Medicine.

We're making genomics the standard of care in the fight against cancer and hereditary disease.

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Our History: Pioneers in Precision Medicine

Invigorated by the sequencing of the human genome, breakthroughs in basic science are now delivering blockbuster therapies in cancer and other critical indications. A key player, Washington University in St. Louis, led the Human Genome Project and was among the first to validate and report its experience utilizing next generation sequencing clinically. While a leader at Washington University, Pierian founder and President Dr. Rakesh Nagarajan was a critical innovator of technology-enabled solutions that allowed for processing and interpreting the near-overwhelming amounts of data created in “omic” analyses. The reputation and critical role of Washington University’s molecular diagnostics lab, as well as Dr. Nagarajan’s ongoing participation in key industry leadership groups such as the College of American Pathologists (CAP), has positioned Pierian as a key enabler of precision medicine.

Human Genome Complete


Washington University in St. Louis plays a crucial role in the mapping of the first human genome.

Clinical Genomics Workspace is Born


Washington University creates CAP/CLIA lab for NGS testing. The Genetics and Molecular Pathology departments collaborate to develop Clinical Genomics Workspace (CGW), groundbreaking software for clinical genomics.

PierianDx Established


Washington University performs a technology transfer after 50+ labs visit to learn how to operationalize clinical NGS testing. Key team members form Pierian. 

Vision Achieves Funding


After two releases of CGW that offer multi-tenant and exome sequencing support, Pierian closes Series A funding (14.2 million).

Pierian Pune, India office
India Office Established


Pierian opens an office in Pune, India to support software development and large-scale biocuration efforts. 

Burgeoning Partner Network


Pierian has 40+ customers supported by nearly 70 medical, scientific, and technical experts.

NovaSeq -- Courtesy of Illumina
Partnership with Industry Leader, Illumina

Early 2019

Pierian partners with Illumina to deliver optimized interpretation and reporting solutions for Illumina pan-cancer profiling assays.

Global Expansion photo by Kyle Glenn
Global Expansion

Mid 2019

Pierian experiences rapid expansion into Europe, Middle East, and Asia Pacific regions. 

Clinical Sharing Network
Mature Partner Network


A network of over 100 clinical institutions contributes knowledge via the partner sharing network.

Our Leadership

Mark McDonough

Mark McDonough

Chief Executive Officer

Rakesh Nagarajan, MD, PhD

Rakesh Nagarajan, MD, PhD

Founder, President, and Chief Technical and Visionary Officer

Chris Callahan

Chris Callahan

Chief Operating Officer, Executive Vice President

James L. Starr

James L. Starr

Chief Financial Officer
Debbie Thompson

Debbie Thompson

Chief People Officer

Lindsay Mateo

Lindsay Mateo

Chief Business Officer

Board of Directors

Joseph Boorady


Operating Partner with Health Catalyst Capital

Bryan Carey


Advisor, Health Catalyst Capital      

Fred Hessler


Retired Managing Director, Health Care Group, Citigroup

Kerry Propper


Co-founder and Managing Director, ATW Partners

Rakesh Nagarajan, MD, PhD


Founder, President, and Chief Technical and Visionary Officer, PierianDx

Mark McDonough


Chief Executive Officer


Barnard Buscemi


Retired Investment Officer, Inova Health System

Other Key Investors

Charles Boorady

Founding Manager

Health Catalyst Capital

Cody Nystrom

Managing Director

SJF Ventures

Matthew Jenkins

Head, Corporate Development

RTI International

Mark Jelley

Board Observer and

Managing Director,
OrbiMed Advisors

Anthony Meyer

Managing Member

Meyer Venture Partners


Work with Us!

Pierian is looking for the best and brightest to join our fast-moving, creative and collaborative team. Join the team that is helping our clients fulfill the promise of personalized medicine.

Career Openings

Upcoming Events

We look forward to meeting you soon! Here's where we'll be next.

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AMP 2020
November 16-20, 2020
March 18-20, 2020
American Society of Clinical Oncology | Chicago, IL
May 31, 2019 - June 4, 2019
November 19-21,2020

What Some of Our Customers Say

About PierianDx

"I knew that with the resources we had, there was no way to create something that would rival a system like the CGW. As we've set up reflex testing in various cancer types, we have been well supported to scale the massive undertaking..."

- Nikoletta Sidiropoulos, MD - Medical Director, University of Vermont Medical Center



“There's going to be a bottleneck in the professional component as well sometimes. Pierian allowed us to widen that bottleneck and to have more uniformity of reporting.”

- Eric Loo, MD - Asst. Professor, Pathology and Lab Medicine, Dartmouth-Hitchcock


“We chose Pierian because their technology combined with expert scientific and clinical services will help accelerate TriCore’s ability to expand our NGS test offerings and provide enhanced clinically actionable information.

- Eric Carbonneau - Director Core Laboratory Operations, TriCore Reference Laboratories


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