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Clinical Genomics Knowledgebase

Be more confident and standardized in your reporting by combining your medical wisdom with that of your peers using the most clinically robust, medically powered knowledgebase for clinical genomics.

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The World's Most Clinically Robust Genomics Knowledgebase

Genomic Variant Interpretations that are Clinically Derived
100%
Somatic Genes Curated
Sequence Coverage
Publications
Distinct Diseases Tested

The PierianDx Knowledgebase is not a variant lookup table. It's built on the foundation of a powerful rules engine that accurately delivers the richest set of rationalized medical interpretations from our clinical customers and Genomic Interpretation Services team, as well as expertly curated genomic data, clinical practice guidelines, FDA therapeutics, and clinical trials.

Rapid and Accurate

In addition to expertly curated sources such as NCCN/ASCO guidelines, FDA therapies, clinical trials, and published literature, our partner sharing network allows for the comparison of classifications and interpretations across medical directors at one or more sites. This unique aspect of the PierianDx KnowledgeBase enables the use of real-world evidence to make knowledge assertions more rapidly and accurately. 

Comprehensive

The PierianDx Knowledgebase encompasses over 6 megabases of sequence coverage (six million genomic variants) and supports all variant types (eg. single nucleotide variants, insertions/deletions, copy number variants, and structural variants) for somatic cancer and germline applications, making it the most comprehensive genomic knowledgebase available.

Medically Powered

All shared genomic interpretations in the PierianDx Knowledgebase are expertly curated by our clinical customers or Interpretation Services team with an acute focus on their impact for clinical care. Each interpretation has medical oversight by our board certified Medical Director or is signed out directly by a board certified molecular pathologist or clinical geneticist.  

Up-to-Date

With real-time publishing of medical interpretations and weekly updates to industry guidelines, FDA therapies and clinical trials, the PierianDx Knowledgebase contains the most up-to-date and clinically actionable information for next generation sequencing data.

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Where do PierianDx Clinical Interpretations Come From?

PierianDx Clinical Genomics Interpretation Sharing Network

Over 40 leading health systems and commercial labs participate with PierianDx in a medical interpretation sharing network to enhance the clinical actionability of the PierianDx Knowledgebase and improve patient care in a rapidly evolving field.

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Resources

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Guide: Evidenced-based Categorization of Somatic Variants

Our convenient guide provides conceptual information for anybody involved in the variant interpretation process for sequence variants in cancer.

Access Guide →
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Webinar: Interpretation and Reporting of Sequence Variants in Cancer

Presenters:
Shalini Verma, MD, FCAP - Medical Director and Laboratory Director, PierianDx

Andy Bredemeyer, PhD - VP of Product, PierianDx

View Webinar →
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Infographic

Our convenient infographic provides an overview of the key steps to interpreting and reporting sequence variants in cancer.

Download Infographic →

Trusted by leading cancer centers, medical centers, health systems and reference laboratories.

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“Working with PierianDx has been an ideal partnership. They have been with us since the early onset of our program, providing both the technology and services that allowed us to ramp our program much faster.”

- Anthony Magliocco, MD - Chair, Anatomic Pathology, Moffitt Cancer Center

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"I knew that with the resources we had, there was no way to create something that would rival a system like the CGW. As we've set up reflex testing in various cancer types, we have been well supported to scale the massive undertaking..."

- Nikoletta Sidiropoulos, MD - Medical Director, University of Vermont Medical Center

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“There's going to be a bottleneck in the professional component as well sometimes. PierianDx allowed us to widen that bottleneck and to have more uniformity of reporting.”

- Eric Loo, MD - Asst. Professor, Pathology and Lab Medicine, Dartmouth-Hitchcock

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“We chose PierianDx because their technology combined with expert scientific and clinical services will help accelerate TriCore’s ability to expand our NGS test offerings and provide enhanced clinically actionable information.

- Eric Carbonneau - Director Core Laboratory Operations, TriCore Reference Laboratories

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“A new partnership with PierianDx expands our reporting to include current clinical trials and up-to- the-minute treatment options, all linked to NorthShore’s Electronic Medical Record.”

- NorthShore University HealthSystem Kellogg Cancer Center 2017 Annual Report

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Experience the PierianDx Knowledgebase in Action

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