The Pierian Knowledgebase is not a variant lookup table. It's built on the foundation of a powerful rules engine that accurately delivers the richest set of rationalized medical interpretations from our clinical customers and Genomic Interpretation Services team, as well as expertly curated genomic data, clinical practice guidelines, FDA therapeutics, and clinical trials.
In addition to expertly curated sources such as NCCN/ASCO guidelines, FDA therapies, clinical trials, and published literature, our partner sharing network allows for the comparison of classifications and interpretations across medical directors at one or more sites. This unique aspect of the Pierian KnowledgeBase enables the use of real-world evidence to make knowledge assertions more rapidly and accurately.
The Pierian Knowledgebase encompasses over 10 megabases of sequence coverage (ten million genomic variants) and supports all variant types (eg. single nucleotide variants, insertions/deletions, copy number variants, and structural variants) for somatic cancer and germline applications, making it the most comprehensive genomic knowledgebase available.
All shared genomic interpretations in the Pierian Knowledgebase are expertly curated by our clinical customers or Interpretation Services team with an acute focus on their impact for clinical care. Each interpretation has medical oversight by our board certified Medical Director or is signed out directly by a board certified molecular pathologist or clinical geneticist.
With real-time publishing of medical interpretations and weekly updates to industry guidelines, FDA therapies and clinical trials, the Pierian Knowledgebase contains the most up-to-date and clinically actionable information for next generation sequencing data.
This webinar provides practical strategies for the analysis of complex genomic alterations such as co-occurring variants, splice-site mutations, and gene fusions.
View Webinar →Presenters:
Shalini Verma, MD, FCAP - Medical Director and Laboratory Director, PierianDx
Andy Bredemeyer, PhD - VP of Product, PierianDx
View Webinar →Learn about the benefits associated with integrating genomic medicine into clinical pathways, along with approaches for pilot programs and recommendations for developing a testing framework.
"I knew that with the resources we had, there was no way to create something that would rival a system like the CGW. As we've set up reflex testing in various cancer types, we have been well supported to scale the massive undertaking..."
- Nikoletta Sidiropoulos, MD - Medical Director, University of Vermont Medical Center
“There's going to be a bottleneck in the professional component as well sometimes. Pierian allowed us to widen that bottleneck and to have more uniformity of reporting.”
- Eric Loo, MD - Asst. Professor, Pathology and Lab Medicine, Dartmouth-Hitchcock
“We chose Pierian because their technology combined with expert scientific and clinical services will help accelerate TriCore’s ability to expand our NGS test offerings and provide enhanced clinically actionable information.”
- Eric Carbonneau - Director Core Laboratory Operations, TriCore Reference Laboratories
“A new partnership with Pierian expands our reporting to include current clinical trials and up-to- the-minute treatment options, all linked to NorthShore’s Electronic Medical Record.”
- NorthShore University HealthSystem Kellogg Cancer Center 2017 Annual Report
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